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MMS21 / YEL019C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

NSE2 9 , PSO10 10
Protein Product
SUMO ligase MMS21
Feature Type
ORF , Verified
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function 1 2 3 4 5 6 7 8