Phenotype Help

RDS1 / YCR106W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

33 entries for 12 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chemical compound accumulation: increased
classical genetics overexpression
Allele: rds1-Δ
S288C reactive oxygen speciesTreatment: furfural, 35 mM
Details: increased proportion of ROS positive cells 16 hours after treatment with furfural
Tafere Abrha G, et al. (2023) PMID:37544800
competitive fitness: increased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: rds1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1.007
Breslow DK, et al. (2008) PMID:18622397
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: rds1-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0059
Pir P, et al. (2012) PMID:22244311
protein activity: increased
Reporter: aldehyde reductase
classical genetics overexpression
Allele: rds1-Δ
S288C35 mM furfuralDetails: increased NADH- and NAD(P)H reductase activity in the furfural treated null mutant relative to wt
Tafere Abrha G, et al. (2023) PMID:37544800
replicative lifespan: increased
classical geneticsnull
Allele: rds1-Δ
S288CMcCormick MA, et al. (2015) PMID:26456335
replicative lifespan: increased
large-scale survey null
Allele: rds1-Δ
S288CDetails: increase in average replicative lifespan (RLS); assayed by single-cell measurement of RLS using a high-throughput microfluidic Yeast Replicator platform
Ölmez TT, et al. (2023) PMID:38012152
resistance to chemicals: decreased
systematic mutation set

serial dilution test; growth measured after 9 days and compared to wildtype

null
Allele: rds1-Δ
S288C1.0 ug/ml cycloheximideAkache B and Turcotte B (2002) PMID:11943786
resistance to chemicals: decreased
systematic mutation set null
Allele: rds1-Δ
S288C180 μM chlorpromazineDetails: increased sensitivity to treatment with chlorpromazine at a concentration of 180 μM, just below the MIC99 of 210 μM on plates
Caldara M, et al. (2017) PMID:28087837
resistance to chemicals: decreased
classical genetics null
Allele: rds1-Δ
S288C promazineDetails: increased sensitivity to treatment with promazine at the MIC75 concentration where 100 μM is the MIC99 in liquid media
Caldara M, et al. (2017) PMID:28087837
resistance to chemicals: decreased
classical genetics null
Allele: rds1-Δ
S288C chlorpromazineDetails: increased sensitivity to treatment with chlorpromazine at the MIC75 concentration where 30 μM is the MIC99 in liquid media
Caldara M, et al. (2017) PMID:28087837
Showing 1 to 10 of 33 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


Resources