Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
33 entries for 12 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| chemical compound accumulation: increased | classical genetics | overexpression Allele: rds1-Δ | S288C | reactive oxygen species | Treatment: furfural, 35 mM Details: increased proportion of ROS positive cells 16 hours after treatment with furfural | Tafere Abrha G, et al. (2023) PMID:37544800 |
| competitive fitness: increased | competitive growth fitness profiling using complete deletion alleles | null Allele: rds1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 1.007 | Breslow DK, et al. (2008) PMID:18622397 | |
| haploinsufficient | heterozygous diploid, competitive growth genome-wide fitness profiling | null Allele: rds1-Δ | S288C | Media: turbidostat growth in FPM medium Details: Relative growth score: -0.0059 | Pir P, et al. (2012) PMID:22244311 | |
| protein activity: increased Reporter: aldehyde reductase | classical genetics | overexpression Allele: rds1-Δ | S288C | 35 mM furfural | Details: increased NADH- and NAD(P)H reductase activity in the furfural treated null mutant relative to wt | Tafere Abrha G, et al. (2023) PMID:37544800 |
| replicative lifespan: increased | classical genetics | null Allele: rds1-Δ | S288C | McCormick MA, et al. (2015) PMID:26456335 | ||
| replicative lifespan: increased | large-scale survey | null Allele: rds1-Δ | S288C | Details: increase in average replicative lifespan (RLS); assayed by single-cell measurement of RLS using a high-throughput microfluidic Yeast Replicator platform | Ölmez TT, et al. (2023) PMID:38012152 | |
| resistance to chemicals: decreased | systematic mutation set serial dilution test; growth measured after 9 days and compared to wildtype | null Allele: rds1-Δ | S288C | 1.0 ug/ml cycloheximide | Akache B and Turcotte B (2002) PMID:11943786 | |
| resistance to chemicals: decreased | systematic mutation set | null Allele: rds1-Δ | S288C | 180 μM chlorpromazine | Details: increased sensitivity to treatment with chlorpromazine at a concentration of 180 μM, just below the MIC99 of 210 μM on plates | Caldara M, et al. (2017) PMID:28087837 |
| resistance to chemicals: decreased | classical genetics | null Allele: rds1-Δ | S288C | promazine | Details: increased sensitivity to treatment with promazine at the MIC75 concentration where 100 μM is the MIC99 in liquid media | Caldara M, et al. (2017) PMID:28087837 |
| resistance to chemicals: decreased | classical genetics | null Allele: rds1-Δ | S288C | chlorpromazine | Details: increased sensitivity to treatment with chlorpromazine at the MIC75 concentration where 30 μM is the MIC99 in liquid media | Caldara M, et al. (2017) PMID:28087837 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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