RRT12 / YCR045C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

RRT12/YCR045C is a non-essential gene; null mutants are viable, slow-growing, and demonstrate several phenotypes including decreased resistance to acidic pH, indicating a compromised ability to thrive in acidic environments; increased cell size, which may reflect alterations in cellular regulation and growth processes; decreased chronological lifespan, suggesting potential impacts on aging and longevity; abnormal colony appearance; decreased competitive fitness, making them less effective in resource competition; reduced resistance to desiccation and increased sensitivity to heat, which may hinder their survival under stress conditions. Null mutants also show decreased resistance to hyperosmotic stress, indicating vulnerabilities in osmotic regulation, diminished replicative lifespan, and decreased respiratory growth, which could affect their energy metabolism. rrt12 null mutants display abnormal spore wall formation and decreased sporulation efficiency, highlighting defects in reproductive processes, and decreased stress and toxin resistance, further emphasizing their compromised fitness. Overexpression of RRT12 leads to a decreased rate of vegetative growth, suggesting that while the gene is essential for normal growth and stress responses, its overexpression may disrupt cellular homeostasis.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources