Literature Help
BIT2 / YBR270C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Gaubitz C, et al. (2015) Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2. Mol Cell 58(6):977-88 PMID:26028537
- Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 PMID:15689497
- Schmidt A, et al. (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci U S A 93(24):13780-5 PMID:8943012
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
Reset
Click on a gene or a paper to go to its specific page within SGD. Drag any of the gene or paper objects around
within the visualization for easier viewing and click “Reset” to automatically redraw the diagram.
Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Zhao Y, et al. (2023) Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions. Cell 186(24):5220-5236.e16 PMID:37944511
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Karuppasamy M, et al. (2017) Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2. Nat Commun 8(1):1729 PMID:29170376
- Yerlikaya S, et al. (2016) TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol Biol Cell 27(2):397-409 PMID:26582391
- Mohammadi S, et al. (2013) Inferring the effective TOR-dependent network: a computational study in yeast. BMC Syst Biol 7:84 PMID:24005029
- Ho HL, et al. (2008) Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling. Eukaryot Cell 7(8):1328-43 PMID:18552287
- Daniel J (2007) Direct in vivo access to potential gene targets of the RPD3 histone deactylase using fitness-based interferential genetics. Yeast 24(7):575-87 PMID:17533620
- Hishigaki H, et al. (2001) Assessment of prediction accuracy of protein function from protein--protein interaction data. Yeast 18(6):523-31 PMID:11284008
- He F, et al. (1997) Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol Cell Biol 17(3):1580-94 PMID:9032286
Reviews
No reviews curated.
Download References (.nbib)
- Emmerstorfer-Augustin A and Thorner J (2023) Regulation of TORC2 Function and Localization in Yeast. Annu Rev Cell Dev Biol 39:363-389 PMID:37339679
- Foltman M and Sanchez-Diaz A (2023) TOR Complex 1: Orchestrating Nutrient Signaling and Cell Cycle Progression. Int J Mol Sci 24(21) PMID:37958727
- Thorner J (2022) TOR complex 2 is a master regulator of plasma membrane homeostasis. Biochem J 479(18):1917-1940 PMID:36149412
- Riggi M, et al. (2020) The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance. J Cell Sci 133(9) PMID:32393676
- Tafur L, et al. (2020) Structural Insights into TOR Signaling. Genes (Basel) 11(8) PMID:32759652
- Locke MN and Thorner J (2019) Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae. Cell Cycle 18(10):1084-1094 PMID:31068077
- Guaragnella N, et al. (2018) New perspectives from South-Y-East, not all about death. A report of the 12th lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017. Microb Cell 5(2):112-115 PMID:29417059
- Olson DK, et al. (2016) Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis. Biochim Biophys Acta 1861(8 Pt B):784-792 PMID:26747648
- Saxena A and Sitaraman R (2016) Osmoregulation in Saccharomyces cerevisiae via mechanisms other than the high-osmolarity glycerol pathway. Microbiology (Reading) 162(9):1511-1526 PMID:27557593
- Teixeira V and Costa V (2016) Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism. Prog Lipid Res 61:109-33 PMID:26703187
- Tsang F and Lin SJ (2015) Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity. Front Biol (Beijing) 10(4):333-357 PMID:27683589
- Rødkaer SV and Faergeman NJ (2014) Glucose- and nitrogen sensing and regulatory mechanisms in Saccharomyces cerevisiae. FEMS Yeast Res 14(5):683-96 PMID:24738657
- Loewith R (2011) A brief history of TOR. Biochem Soc Trans 39(2):437-42 PMID:21428915
- Jacinto E (2008) What controls TOR? IUBMB Life 60(8):483-96 PMID:18493947
- Rohde JR, et al. (2008) Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 11(2):153-60 PMID:18396450
- De Virgilio C and Loewith R (2006) Cell growth control: little eukaryotes make big contributions. Oncogene 25(48):6392-415 PMID:17041625
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 PMID:15689497
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Andrade Latino A and Biggins S (2025) Analysis of a cancer-associated mutation in the budding yeast Nuf2 kinetochore protein. MicroPubl Biol 2025 PMID:40161439
- Carey SB, et al. (2023) A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast. G3 (Bethesda) 13(1) PMID:36409020
- Cohen N, et al. (2023) A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon. EMBO J 42(11):e113385 PMID:37073826
- Kolhe JA, et al. (2023) The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions. Mol Cell 83(12):2035-2044.e7 PMID:37295430
- Lehner MH, et al. (2022) Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Rep 41(4):111536 PMID:36288698
- Lu PYT, et al. (2022) A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans. Genetics 222(3) PMID:36066422
- Chao JT, et al. (2019) Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Dev Cell 51(2):173-191.e5 PMID:31564614
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Makrantoni V, et al. (2017) A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis. G3 (Bethesda) 7(9):3203-3215 PMID:28754723
- Babour A, et al. (2016) The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis. Cell 167(5):1201-1214.e15 PMID:27863241
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Steunou AL, et al. (2016) Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol Cell Biol 36(22):2768-2781 PMID:27550811
- Freeberg MA, et al. (2013) Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae. Genome Biol 14(2):R13 PMID:23409723
- Van de Vosse DW, et al. (2013) A role for the nucleoporin Nup170p in chromatin structure and gene silencing. Cell 152(5):969-83 PMID:23452847
- Moehle EA, et al. (2012) The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. PLoS Genet 8(11):e1003101 PMID:23209445
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Daniel J (2007) Direct in vivo access to potential gene targets of the RPD3 histone deactylase using fitness-based interferential genetics. Yeast 24(7):575-87 PMID:17533620
- Johansson MJ, et al. (2007) Association of yeast Upf1p with direct substrates of the NMD pathway. Proc Natl Acad Sci U S A 104(52):20872-7 PMID:18087042
- Fadri M, et al. (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900 PMID:15689497
- Ptacek J, et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84 PMID:16319894
- Cagney G, et al. (2001) Two-hybrid analysis of the Saccharomyces cerevisiae 26S proteasome. Physiol Genomics 7(1):27-34 PMID:11595789
- Ito T, et al. (2001) A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A 98(8):4569-74 PMID:11283351
- Uetz P, et al. (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770):623-7 PMID:10688190
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Pallares RM, et al. (2022) Identifying Toxicity Mechanisms Associated with Early Lanthanide Exposure through Multidimensional Genome-Wide Screening. ACS Omega 7(38):34412-34419 PMID:36188298
- Helsen J, et al. (2020) Gene Loss Predictably Drives Evolutionary Adaptation. Mol Biol Evol 37(10):2989-3002 PMID:32658971
- Stenger M, et al. (2020) Systematic analysis of nuclear gene function in respiratory growth and expression of the mitochondrial genome in S. cerevisiae. Microb Cell 7(9):234-249 PMID:32904421
- St John N, et al. (2020) Genome Profiling for Aflatoxin B1 Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B1-Associated DNA Damage. G3 (Bethesda) 10(11):3929-3947 PMID:32994210
- Porcu G, et al. (2013) Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines. Mol Cancer 12(1):88 PMID:23915247
- Pir P, et al. (2012) The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol 6:4 PMID:22244311
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Brown JA, et al. (2006) Global analysis of gene function in yeast by quantitative phenotypic profiling. Mol Syst Biol 2:2006.0001 PMID:16738548
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549