TDP1 / YBR223C Homology


Standard Name
TDP1 1
Systematic Name
YBR223C
SGD ID
SGD:S000000427
Feature Type
ORF , Verified
Description
Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II, including DNA-protein cross-links; mutations in the human homolog, TDP1, result in the neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN) 1 2 3 4 5 6
Name Description
Tyrosyl-DNA Phosphodiesterase 1
Comparative Info

Homologs

Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.


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Species Gene ID Gene name Source

Functional Complementation

Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).


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Gene Species Gene ID Strain background Direction Details Source Reference

Fungal Homologs

Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.


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Species Gene ID Gene name Description Source

External Identifiers

List of external identifiers for the protein from various database sources.


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External ID Source

Resources