Phenotype Help

MSI1 / YBR195C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

33 entries for 16 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
cell cycle progression through the G2/M phase transition: delayed
homozygous diploid, large-scale surveynull
Allele: msi1-Δ
S288CDetails: cells accumulate with 2C DNA content (HTP flow cytometry) indicative of a G2/M phase delay
White MA, et al. (2009) PMID:19033152
chromosome/plasmid maintenance: abnormal
homozygous diploidnull
Allele: msi1-Δ
S288CDetails: loss of heterozygosity at the MET15 locus increased 6-20 fold, but not changed at MAT or SAM2 loci
Andersen MP, et al. (2008) PMID:18562670
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: msi1-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.923
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: decreased
systematic mutation setnull
Allele: msi1-Δ
S288CMedia: rich medium (YPD) w/6% ethanol, ETH
Qian W, et al. (2012) PMID:23103169
competitive fitness: increased
systematic mutation setnull
Allele: msi1-Δ
S288CMedia: synthetic complete medium, SC
Qian W, et al. (2012) PMID:23103169
metal resistance: decreased
systematic mutation set overexpressionS288C2 mM copper(II) sulfateDetails: exacerbates toxicity
Chakrabortee S, et al. (2016) PMID:27693355
metal resistance: decreased
homozygous diploid, systematic mutation set null
Allele: msi1-Δ
S288C2.4 mM aluminium(3+)Treatment: aluminium sulfate, 2.4 mM
Schulze Y, et al. (2023) PMID:37193668
metal resistance: decreased
homozygous diploid, systematic mutation set null
Allele: msi1-Δ
S288C5.0 mM gallium(3+)Treatment: gallium trichloride, 5.0 mM
Schulze Y, et al. (2023) PMID:37193668
metal resistance: decreased
homozygous diploid, systematic mutation set null
Allele: msi1-Δ
S288C2.6 mM indium(3+)Treatment: indium chloride, 2.6 mM
Schulze Y, et al. (2023) PMID:37193668
oxidative stress resistance: decreased
competitive growth null
Allele: msi1-Δ
S288C1 mM paraquatHelsen J, et al. (2020) PMID:32658971
Showing 1 to 10 of 33 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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