Literature Help
YPC1 / YBR183W Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Mülleder M, et al. (2016) Functional Metabolomics Describes the Yeast Biosynthetic Regulome. Cell 167(2):553-565.e12 PMID:27693354
- Villasmil ML, et al. (2016) Ceramide signals for initiation of yeast mating-specific cell cycle arrest. Cell Cycle 15(3):441-54 PMID:26726837
- Yi JK, et al. (2016) Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function. Oncotarget 7(16):21124-44 PMID:27008706
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Voynova NS, et al. (2015) Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Eukaryot Cell 14(12):1203-16 PMID:26432633
- Voynova NS, et al. (2014) Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1. FEMS Yeast Res 14(5):776-88 PMID:24866405
- Ramachandra N and Conzelmann A (2013) Membrane topology of yeast alkaline ceramidase YPC1. Biochem J 452(3):585-94 PMID:23445175
- Voynova NS, et al. (2012) A novel pathway of ceramide metabolism in Saccharomyces cerevisiae. Biochem J 447(1):103-14 PMID:22738231
- Cerantola V, et al. (2009) Aureobasidin A arrests growth of yeast cells through both ceramide intoxication and deprivation of essential inositolphosphorylceramides. Mol Microbiol 71(6):1523-37 PMID:19210614
- Villa NY, et al. (2009) Sphingolipids function as downstream effectors of a fungal PAQR. Mol Pharmacol 75(4):866-75 PMID:19066337
- Pata MO, et al. (2008) Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice. Plant J 55(6):1000-9 PMID:18547394
- Galadari S, et al. (2006) Identification of a novel amidase motif in neutral ceramidase. Biochem J 393(Pt 3):687-95 PMID:16229686
- Proszynski TJ, et al. (2005) A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc Natl Acad Sci U S A 102(50):17981-6 PMID:16330752
- Jiang JC, et al. (2004) Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity. Exp Gerontol 39(7):999-1009 PMID:15236759
- Kim JH, et al. (2004) Secondary metabolites of the grapevine pathogen Eutypa lata inhibit mitochondrial respiration, based on a model bioassay using the yeast Saccharomyces cerevisiae. Curr Microbiol 49(4):282-7 PMID:15386117
- Schorling S, et al. (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell 12(11):3417-27 PMID:11694577
- de Groot PW, et al. (2001) A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae. Comp Funct Genomics 2(3):124-42 PMID:18628907
- Mao C, et al. (2000) Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J Biol Chem 275(40):31369-78 PMID:10900202
- Mao C, et al. (2000) Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem 275(10):6876-84 PMID:10702247
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
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Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Liu S, et al. (2023) The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy. Nat Commun 14(1):3725 PMID:37349354
- Zhong L, et al. (2018) Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri. PLoS One 13(3):e0194863 PMID:29590184
- Chen PW, et al. (2016) Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast. PLoS One 11(1):e0146839 PMID:26784947
- Edvardson S, et al. (2016) Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy. J Med Genet 53(6):389-96 PMID:26792856
- Mallela SK, et al. (2016) Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. PLoS One 11(1):e0145831 PMID:26752183
- Rego A, et al. (2012) Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS One 7(11):e48571 PMID:23226203
- Ambroset C, et al. (2011) Deciphering the molecular basis of wine yeast fermentation traits using a combined genetic and genomic approach. G3 (Bethesda) 1(4):263-81 PMID:22384338
- Cocklin R, et al. (2011) New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1. Genetics 187(3):701-15 PMID:21196523
- Kavun Ozbayraktar FB and Ulgen KO (2011) Stoichiometric network reconstruction and analysis of yeast sphingolipid metabolism incorporating different states of hydroxylation. Biosystems 104(1):63-75 PMID:21215790
- Villa-García MJ, et al. (2011) Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics 285(2):125-49 PMID:21136082
- Vionnet C, et al. (2011) Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors. J Biol Chem 286(8):6769-79 PMID:21173150
- Dawaliby R and Mayer A (2010) Microautophagy of the nucleus coincides with a vacuolar diffusion barrier at nuclear-vacuolar junctions. Mol Biol Cell 21(23):4173-83 PMID:20943953
- Li BZ, et al. (2010) Transcriptome analysis of differential responses of diploid and haploid yeast to ethanol stress. J Biotechnol 148(4):194-203 PMID:20561546
- Mira NP, et al. (2010) Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid. OMICS 14(5):587-601 PMID:20955010
- Guan XL, et al. (2009) Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell 20(7):2083-95 PMID:19225153
- Ye Y, et al. (2009) Gaining insight into the response logic of Saccharomyces cerevisiae to heat shock by combining expression profiles with metabolic pathways. Biochem Biophys Res Commun 385(3):357-62 PMID:19463789
- Mousley CJ, et al. (2008) Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast. Mol Biol Cell 19(11):4785-803 PMID:18753406
- Cerantola V, et al. (2007) Yeast sphingolipids do not need to contain very long chain fatty acids. Biochem J 401(1):205-16 PMID:16987101
- Hirasawa T, et al. (2007) Identification of target genes conferring ethanol stress tolerance to Saccharomyces cerevisiae based on DNA microarray data analysis. J Biotechnol 131(1):34-44 PMID:17604866
- Gaigg B, et al. (2005) Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast. J Biol Chem 280(23):22515-22 PMID:15817474
- Zhang W, et al. (2003) Microarray analyses of the metabolic responses of Saccharomyces cerevisiae to organic solvent dimethyl sulfoxide. J Ind Microbiol Biotechnol 30(1):57-69 PMID:12545388
- Higgins VJ, et al. (2002) Phenotypic analysis of gene deletant strains for sensitivity to oxidative stress. Yeast 19(3):203-14 PMID:11816028
- Mao C, et al. (2001) Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem 276(28):26577-88 PMID:11356846
- Zhang CT and Wang J (2000) Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve. Nucleic Acids Res 28(14):2804-14 PMID:10908339
Reviews
No reviews curated.
Download References (.nbib)
- Tani M (2024) Biological Importance of Complex Sphingolipids and Their Structural Diversity in Budding Yeast Saccharomyces cerevisiae. Int J Mol Sci 25(22) PMID:39596489
- Wang Y, et al. (2023) TORC1 Signaling in Fungi: From Yeasts to Filamentous Fungi. Microorganisms 11(1) PMID:36677510
- Wang Z, et al. (2023) Key enzymes involved in the utilization of fatty acids by Saccharomyces cerevisiae: a review. Front Microbiol 14:1294182 PMID:38274755
- Schlarmann P, et al. (2021) Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis. Membranes (Basel) 11(12) PMID:34940472
- Xu R, et al. (2021) Alkaline ceramidase family: The first two decades. Cell Signal 78:109860 PMID:33271224
- Deprez MA, et al. (2018) The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 18(5) PMID:29788208
- Marquês JT, et al. (2018) Sphingolipid hydroxylation in mammals, yeast and plants - An integrated view. Prog Lipid Res 71:18-42 PMID:29746894
- Mitrofanova D, et al. (2018) Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae. Front Biosci (Landmark Ed) 23(6):1166-1194 PMID:28930594
- Tani M and Funato K (2018) Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast. Curr Genet 64(5):1021-1028 PMID:29556757
- Megyeri M, et al. (2016) Making Sense of the Yeast Sphingolipid Pathway. J Mol Biol 428(24 Pt A):4765-4775 PMID:27664439
- Klug L and Daum G (2014) Yeast lipid metabolism at a glance. FEMS Yeast Res 14(3):369-88 PMID:24520995
- Montefusco DJ, et al. (2014) The yeast sphingolipid signaling landscape. Chem Phys Lipids 177:26-40 PMID:24220500
- Rego A, et al. (2014) The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids. FEMS Yeast Res 14(1):160-78 PMID:24103214
- Van Brocklyn JR and Williams JB (2012) The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death. Comp Biochem Physiol B Biochem Mol Biol 163(1):26-36 PMID:22613819
- Kihara A, et al. (2007) Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog Lipid Res 46(2):126-44 PMID:17449104
- Jenkins GM (2003) The emerging role for sphingolipids in the eukaryotic heat shock response. Cell Mol Life Sci 60(4):701-10 PMID:12785717
- Warnecke D and Heinz E (2003) Recently discovered functions of glucosylceramides in plants and fungi. Cell Mol Life Sci 60(5):919-41 PMID:12827281
- Funato K, et al. (2002) Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae. Biochemistry 41(51):15105-14 PMID:12484746
- Hannun YA, et al. (2001) Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry 40(16):4893-903 PMID:11305904
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Voynova NS, et al. (2014) Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1. FEMS Yeast Res 14(5):776-88 PMID:24866405
- Schorling S, et al. (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell 12(11):3417-27 PMID:11694577
- Mao C, et al. (2000) Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. J Biol Chem 275(40):31369-78 PMID:10900202
- Mao C, et al. (2000) Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem 275(10):6876-84 PMID:10702247
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Download References (.nbib)
- Proszynski TJ, et al. (2005) A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc Natl Acad Sci U S A 102(50):17981-6 PMID:16330752
- de Groot PW, et al. (2001) A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae. Comp Funct Genomics 2(3):124-42 PMID:18628907
- Mao C, et al. (2000) Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. J Biol Chem 275(10):6876-84 PMID:10702247
Disease Literature
Paper(s) associated with one or more pieces of disease evidence in SGD, as found on the Disease page.
No disease literature curated.
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Rajakumar T, et al. (2024) Dysregulation of ceramide metabolism causes phytoceramide-dependent induction of the unfolded protein response. Mol Biol Cell 35(9):ar117 PMID:39024283
- Cohen N, et al. (2023) A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon. EMBO J 42(11):e113385 PMID:37073826
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Teixeira V, et al. (2016) Ceramide signaling targets the PP2A-like protein phosphatase Sit4p to impair vacuolar function, vesicular trafficking and autophagy in Isc1p deficient cells. Biochim Biophys Acta 1861(1):21-33 PMID:26477382
- Fröhlich F, et al. (2015) The GARP complex is required for cellular sphingolipid homeostasis. Elife 4 PMID:26357016
- Voynova NS, et al. (2015) Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Eukaryot Cell 14(12):1203-16 PMID:26432633
- Swinnen E, et al. (2014) The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell 25(1):196-211 PMID:24196832
- Freeberg MA, et al. (2013) Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae. Genome Biol 14(2):R13 PMID:23409723
- Surma MA, et al. (2013) A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress. Mol Cell 51(4):519-30 PMID:23891562
- Kaluarachchi Duffy S, et al. (2012) Exploring the yeast acetylome using functional genomics. Cell 149(4):936-48 PMID:22579291
- Mousley CJ, et al. (2012) A sterol-binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing. Cell 148(4):702-15 PMID:22341443
- Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40 PMID:21987634
- Mitchell L, et al. (2011) Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4. PLoS One 6(10):e25336 PMID:21984913
- Stirling PC, et al. (2011) The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet 7(4):e1002057 PMID:21552543
- Szappanos B, et al. (2011) An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat Genet 43(7):656-62 PMID:21623372
- Vionnet C, et al. (2011) Yeast cells lacking all known ceramide synthases continue to make complex sphingolipids and to incorporate ceramides into glycosylphosphatidylinositol (GPI) anchors. J Biol Chem 286(8):6769-79 PMID:21173150
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- Miller JP, et al. (2005) Large-scale identification of yeast integral membrane protein interactions. Proc Natl Acad Sci U S A 102(34):12123-8 PMID:16093310
- Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19 PMID:16269340
- Jiang JC, et al. (2004) Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity. Exp Gerontol 39(7):999-1009 PMID:15236759
- Roelants FM, et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 PMID:12221112
- Schorling S, et al. (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol Biol Cell 12(11):3417-27 PMID:11694577
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Chakrabortee S, et al. (2016) Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits. Cell 167(2):369-381.e12 PMID:27693355
- Mülleder M, et al. (2016) Functional Metabolomics Describes the Yeast Biosynthetic Regulome. Cell 167(2):553-565.e12 PMID:27693354
- Ellahi A, et al. (2015) The Chromatin and Transcriptional Landscape of Native Saccharomyces cerevisiae Telomeres and Subtelomeric Domains. Genetics 200(2):505-21 PMID:25823445
- Gaupel AC, et al. (2014) High throughput screening identifies modulators of histone deacetylase inhibitors. BMC Genomics 15(1):528 PMID:24968945
- Michaillat L and Mayer A (2013) Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. PLoS One 8(2):e54160 PMID:23383298
- Pir P, et al. (2012) The genetic control of growth rate: a systems biology study in yeast. BMC Syst Biol 6:4 PMID:22244311
- Teng X, et al. (2011) Gene-dependent cell death in yeast. Cell Death Dis 2(8):e188 PMID:21814286
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Villa-García MJ, et al. (2011) Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. Mol Genet Genomics 285(2):125-49 PMID:21136082
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- MacIsaac KD, et al. (2006) An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC Bioinformatics 7:113 PMID:16522208
- Mendiratta G, et al. (2006) The DNA-binding domain of the yeast Spt10p activator includes a zinc finger that is homologous to foamy virus integrase. J Biol Chem 281(11):7040-8 PMID:16415340
- Proszynski TJ, et al. (2005) A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc Natl Acad Sci U S A 102(50):17981-6 PMID:16330752
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549
- Higgins VJ, et al. (2002) Phenotypic analysis of gene deletant strains for sensitivity to oxidative stress. Yeast 19(3):203-14 PMID:11816028