Literature Help
SMY2 / YBR172C Literature
All manually curated literature for the specified gene, organized by relevance to the gene and by
association with specific annotations to the gene in SGD. SGD gathers references via a PubMed search for
papers whose titles or abstracts contain “yeast” or “cerevisiae;” these papers are reviewed manually and
linked to relevant genes and literature topics by SGD curators.
Primary Literature
Literature that either focuses on the gene or contains information about function, biological role,
cellular location, phenotype, regulation, structure, or disease homologs in other species for the gene
or gene product.
No primary literature curated.
Download References (.nbib)
- Lehner MH, et al. (2022) Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Rep 41(4):111536 PMID:36288698
- Veltri AJ, et al. (2022) Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation. Elife 11 PMID:35894211
- Schmitt K, et al. (2021) A Multi-Perspective Proximity View on the Dynamic Head Region of the Ribosomal 40S Subunit. Int J Mol Sci 22(21) PMID:34769086
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- McCormick MA, et al. (2015) A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab 22(5):895-906 PMID:26456335
- Ash MR, et al. (2010) Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes. Structure 18(8):944-54 PMID:20696395
- Buchanan R, et al. (2010) Genetic analysis of yeast Sec24p mutants suggests cargo binding is not co-operative during ER export. Traffic 11(8):1034-43 PMID:20477990
- Sezen B, et al. (2009) The SESA network links duplication of the yeast centrosome with the protein translation machinery. Genes Dev 23(13):1559-70 PMID:19571182
- Higashio H, et al. (2008) Smy2p participates in COPII vesicle formation through the interaction with Sec23p/Sec24p subcomplex. Traffic 9(1):79-93 PMID:17973654
- Georgiev A, et al. (2007) Binding specificities of the GYF domains from two Saccharomyces cerevisiae paralogs. Protein Eng Des Sel 20(9):443-52 PMID:17804396
- Kofler M, et al. (2005) GYF domain proteomics reveals interaction sites in known and novel target proteins. Mol Cell Proteomics 4(11):1797-811 PMID:16120600
- Andoh T, et al. (2004) The fission yeast ptr1+ gene involved in nuclear mRNA export encodes a putative ubiquitin ligase. Biochem Biophys Res Commun 317(4):1138-43 PMID:15094387
- Lillie SH and Brown SS (1994) Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae. J Cell Biol 125(4):825-42 PMID:8188749
- Schaaff-Gerstenschläger I, et al. (1993) Sequence and function analysis of a 4.3 kb fragment of Saccharomyces cerevisiae chromosome II including three open reading frames. Yeast 9(8):915-21 PMID:8212898
Related Literature
Genes that share literature (indicated by the purple circles) with the specified gene (indicated by yellow circle).
Reset
Click on a gene or a paper to go to its specific page within SGD. Drag any of the gene or paper objects around
within the visualization for easier viewing and click “Reset” to automatically redraw the diagram.
Additional Literature
Papers that show experimental evidence for the gene or describe homologs in other species, but
for which the gene is not the paper’s principal focus.
No additional literature curated.
Download References (.nbib)
- Sobti M, et al. (2023) Molecular basis for GIGYF-TNRC6 complex assembly. RNA 29(6):724-734 PMID:36854607
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Hickey KL, et al. (2020) GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control. Mol Cell 79(6):950-962.e6 PMID:32726578
- Ergüden B (2019) Dhh1 is a member of the SESA network. Yeast 36(2):99-105 PMID:30346046
- Okano A, et al. (2015) SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations. Biosci Biotechnol Biochem 79(9):1481-3 PMID:25849478
- Lachowiec J, et al. (2013) The protein chaperone HSP90 can facilitate the divergence of gene duplicates. Genetics 193(4):1269-77 PMID:23410833
- Chang J, et al. (2012) Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5. Nucleic Acids Res 40(10):4539-52 PMID:22287628
- Zhang KX and Ouellette BF (2009) GAIA: a gram-based interaction analysis tool--an approach for identifying interacting domains in yeast. BMC Bioinformatics 10 Suppl 1(Suppl 1):S60 PMID:19208164
- Giorgini F, et al. (2008) Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. J Biol Chem 283(12):7390-400 PMID:18079112
- Wang Q, et al. (2008) A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast. Nucleic Acids Res 36(8):2787-98 PMID:18375978
- Rautio JJ, et al. (2007) Monitoring yeast physiology during very high gravity wort fermentations by frequent analysis of gene expression. Yeast 24(9):741-60 PMID:17605133
- Gruhler A, et al. (2005) Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway. Mol Cell Proteomics 4(3):310-27 PMID:15665377
- Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 PMID:14562095
- Kellis M, et al. (2003) Sequencing and comparison of yeast species to identify genes and regulatory elements. Nature 423(6937):241-54 PMID:12748633
- Cullen CF, et al. (2000) A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast. Genetics 155(4):1521-34 PMID:10924454
- Nishizawa K, et al. (1998) Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. Proc Natl Acad Sci U S A 95(25):14897-902 PMID:9843987
- Feldmann H, et al. (1994) Complete DNA sequence of yeast chromosome II. EMBO J 13(24):5795-809 PMID:7813418
Reviews
No reviews curated.
Gene Ontology Literature
Paper(s) associated with one or more GO (Gene Ontology) terms in SGD for the specified gene.
No gene ontology literature curated.
Download References (.nbib)
- Lehner MH, et al. (2022) Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Rep 41(4):111536 PMID:36288698
- Yofe I, et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat Methods 13(4):371-378 PMID:26928762
- Higashio H, et al. (2008) Smy2p participates in COPII vesicle formation through the interaction with Sec23p/Sec24p subcomplex. Traffic 9(1):79-93 PMID:17973654
- Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 PMID:14562095
Phenotype Literature
Paper(s) associated with one or more pieces of classical phenotype evidence in SGD for the specified gene.
No phenotype literature curated.
Interaction Literature
Paper(s) associated with evidence supporting a physical or genetic interaction between the
specified gene and another gene in SGD. Currently, all interaction evidence is obtained from
BioGRID.
No interaction literature curated.
Download References (.nbib)
- Andrade Latino A and Biggins S (2025) Analysis of a cancer-associated mutation in the budding yeast Nuf2 kinetochore protein. MicroPubl Biol 2025 PMID:40161439
- Casler JC, et al. (2024) Mitochondria-ER-PM contacts regulate mitochondrial division and PI(4)P distribution. J Cell Biol 223(9) PMID:38781029
- O'Brien MJ and Ansari A (2024) Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle. Biochim Biophys Acta Proteins Proteom 1872(1):140968 PMID:37863410
- Cohen N, et al. (2023) A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon. EMBO J 42(11):e113385 PMID:37073826
- Michaelis AC, et al. (2023) The social and structural architecture of the yeast protein interactome. Nature 624(7990):192-200 PMID:37968396
- Mishra PK, et al. (2023) Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability. Mol Biol Cell 34(10):ar99 PMID:37436802
- Smurova K, et al. (2023) Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores. Nat Commun 14(1):3172 PMID:37263996
- Gutiérrez-Santiago F, et al. (2022) A High-Copy Suppressor Screen Reveals a Broad Role of Prefoldin-like Bud27 in the TOR Signaling Pathway in Saccharomyces cerevisiae. Genes (Basel) 13(5) PMID:35627133
- Lehner MH, et al. (2022) Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Rep 41(4):111536 PMID:36288698
- Mattingly M, et al. (2022) Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion. Curr Biol 32(13):2884-2896.e6 PMID:35654035
- Schmitt K, et al. (2021) A Multi-Perspective Proximity View on the Dynamic Head Region of the Ribosomal 40S Subunit. Int J Mol Sci 22(21) PMID:34769086
- Sanders E, et al. (2020) Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1. G3 (Bethesda) 10(12):4359-4368 PMID:33115720
- Schoppe J, et al. (2020) AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering. EMBO J 39(20):e105117 PMID:32840906
- Wang Y, et al. (2020) Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase. J Cell Biol 219(5) PMID:32303746
- Ergüden B (2019) Dhh1 is a member of the SESA network. Yeast 36(2):99-105 PMID:30346046
- Miller JE, et al. (2018) Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4. G3 (Bethesda) 8(1):315-330 PMID:29158339
- Opitz N, et al. (2017) Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast. Mol Cell Proteomics 16(12):2199-2218 PMID:28982715
- Babour A, et al. (2016) The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis. Cell 167(5):1201-1214.e15 PMID:27863241
- Buser R, et al. (2016) The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress. PLoS Genet 12(2):e1005843 PMID:26849847
- Costanzo M, et al. (2016) A global genetic interaction network maps a wiring diagram of cellular function. Science 353(6306) PMID:27708008
- Delaveau T, et al. (2016) Tma108, a putative M1 aminopeptidase, is a specific nascent chain-associated protein in Saccharomyces cerevisiae. Nucleic Acids Res 44(18):8826-8841 PMID:27580715
- Tatjer L, et al. (2016) The Saccharomyces cerevisiae Ptc1 protein phosphatase attenuates G2-M cell cycle blockage caused by activation of the cell wall integrity pathway. Mol Microbiol 101(4):671-87 PMID:27169355
- Castelli LM, et al. (2015) The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation. PLoS Genet 11(5):e1005233 PMID:25973932
- Kershaw CJ, et al. (2015) Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p. Sci Rep 5:15518 PMID:26493364
- Kırlı K, et al. (2015) A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Elife 4 PMID:26673895
- Okano A, et al. (2015) SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations. Biosci Biotechnol Biochem 79(9):1481-3 PMID:25849478
- Sezen B (2015) Reduction of Saccharomyces cerevisiae Pom34 protein level by SESA network is related to membrane lipid composition. FEMS Yeast Res 15(8) PMID:26419396
- Elbaz-Alon Y, et al. (2014) A dynamic interface between vacuoles and mitochondria in yeast. Dev Cell 30(1):95-102 PMID:25026036
- Mitchell SF, et al. (2013) Global analysis of yeast mRNPs. Nat Struct Mol Biol 20(1):127-33 PMID:23222640
- Chang J, et al. (2012) Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5. Nucleic Acids Res 40(10):4539-52 PMID:22287628
- Kaluarachchi Duffy S, et al. (2012) Exploring the yeast acetylome using functional genomics. Cell 149(4):936-48 PMID:22579291
- Wang Y, et al. (2012) Coiled-coil networking shapes cell molecular machinery. Mol Biol Cell 23(19):3911-22 PMID:22875988
- Echtenkamp FJ, et al. (2011) Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol Cell 43(2):229-41 PMID:21777812
- Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40 PMID:21987634
- Magtanong L, et al. (2011) Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nat Biotechnol 29(6):505-11 PMID:21572441
- Mitchell L, et al. (2011) Regulation of septin dynamics by the Saccharomyces cerevisiae lysine acetyltransferase NuA4. PLoS One 6(10):e25336 PMID:21984913
- Ash MR, et al. (2010) Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes. Structure 18(8):944-54 PMID:20696395
- Buchanan R, et al. (2010) Genetic analysis of yeast Sec24p mutants suggests cargo binding is not co-operative during ER export. Traffic 11(8):1034-43 PMID:20477990
- Costanzo M, et al. (2010) The genetic landscape of a cell. Science 327(5964):425-31 PMID:20093466
- Ossareh-Nazari B, et al. (2010) Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy. EMBO Rep 11(7):548-54 PMID:20508643
- Ranjitkar P, et al. (2010) An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Mol Cell 40(3):455-64 PMID:21070971
- Batisse J, et al. (2009) Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. J Biol Chem 284(50):34911-7 PMID:19840948
- Sezen B, et al. (2009) The SESA network links duplication of the yeast centrosome with the protein translation machinery. Genes Dev 23(13):1559-70 PMID:19571182
- Hasegawa Y, et al. (2008) Distinct roles for Khd1p in the localization and expression of bud-localized mRNAs in yeast. RNA 14(11):2333-47 PMID:18805955
- Strome ED, et al. (2008) Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Genetics 178(3):1193-207 PMID:18245329
- Wang Q, et al. (2008) A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast. Nucleic Acids Res 36(8):2787-98 PMID:18375978
- Protchenko O, et al. (2006) A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. J Biol Chem 281(30):21445-21457 PMID:16717099
- Zhao R, et al. (2005) Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 120(5):715-27 PMID:15766533
- Briand JF, et al. (2001) Partners of Rpb8p, a small subunit shared by yeast RNA polymerases I, II and III. Mol Cell Biol 21(17):6056-65 PMID:11486042
- Fromont-Racine M, et al. (1997) Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Nat Genet 16(3):277-82 PMID:9207794
Regulation Literature
Paper(s) associated with one or more pieces of regulation evidence in SGD, as found on the
Regulation page.
No regulation literature curated.
Post-translational Modifications Literature
Paper(s) associated with one or more pieces of post-translational modifications evidence in SGD.
No post-translational modifications literature curated.
Download References (.nbib)
- Zhang F, et al. (2025) The Yeast Gsk-3 Kinase Mck1 Is Necessary for Cell Wall Remodeling in Glucose-Starved and Cell Wall-Stressed Cells. Int J Mol Sci 26(8) PMID:40332024
- Leutert M, et al. (2023) The regulatory landscape of the yeast phosphoproteome. Nat Struct Mol Biol 30(11):1761-1773 PMID:37845410
- Lanz MC, et al. (2021) In-depth and 3-dimensional exploration of the budding yeast phosphoproteome. EMBO Rep 22(2):e51121 PMID:33491328
- Zhou X, et al. (2021) Cross-compartment signal propagation in the mitotic exit network. Elife 10 PMID:33481703
- MacGilvray ME, et al. (2020) Phosphoproteome Response to Dithiothreitol Reveals Unique Versus Shared Features of Saccharomyces cerevisiae Stress Responses. J Proteome Res 19(8):3405-3417 PMID:32597660
- Chen YC, et al. (2018) Glucose intake hampers PKA-regulated HSP90 chaperone activity. Elife 7 PMID:30516470
- Bontron S, et al. (2013) Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A. Cell Rep 3(1):16-22 PMID:23273919
- Swaney DL, et al. (2013) Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods 10(7):676-82 PMID:23749301
- Pultz D, et al. (2012) Global mapping of protein phosphorylation events identifies Ste20, Sch9 and the cell-cycle regulatory kinases Cdc28/Pho85 as mediators of fatty acid starvation responses in Saccharomyces cerevisiae. Mol Biosyst 8(3):796-803 PMID:22218487
- Soulard A, et al. (2010) The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates. Mol Biol Cell 21(19):3475-86 PMID:20702584
- Holt LJ, et al. (2009) Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 325(5948):1682-6 PMID:19779198
- Albuquerque CP, et al. (2008) A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol Cell Proteomics 7(7):1389-96 PMID:18407956
- Gruhler A, et al. (2005) Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway. Mol Cell Proteomics 4(3):310-27 PMID:15665377
- Ficarro SB, et al. (2002) Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol 20(3):301-5 PMID:11875433
High-Throughput Literature
Paper(s) associated with one or more pieces of high-throughput evidence in SGD.
No high-throughput literature curated.
Download References (.nbib)
- Guan M, et al. (2023) Delving into the molecular initiating event of cadmium toxification via the dose-dependent functional genomics approach in Saccharomyces cerevisiae. Environ Pollut 323:121287 PMID:36791950
- Jin X, et al. (2021) Retromer Complex and PI3K Complex II-Related Genes Mediate the Yeast (Saccharomyces cerevisiae) Sodium Metabisulfite Resistance Response. Cells 10(12) PMID:34944020
- Molin M, et al. (2020) Protein kinase A controls yeast growth in visible light. BMC Biol 18(1):168 PMID:33198745
- Chakrabortee S, et al. (2016) Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits. Cell 167(2):369-381.e12 PMID:27693355
- Jakubkova M, et al. (2016) Identification of Yeast Mutants Exhibiting Altered Sensitivity to Valinomycin and Nigericin Demonstrate Pleiotropic Effects of Ionophores on Cellular Processes. PLoS One 11(10):e0164175 PMID:27711131
- Gaupel AC, et al. (2014) High throughput screening identifies modulators of histone deacetylase inhibitors. BMC Genomics 15(1):528 PMID:24968945
- Winter G, et al. (2014) Formation of hydrogen sulfide from cysteine in Saccharomyces cerevisiae BY4742: genome wide screen reveals a central role of the vacuole. PLoS One 9(12):e113869 PMID:25517415
- Michaillat L and Mayer A (2013) Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiae. PLoS One 8(2):e54160 PMID:23383298
- Tun NM, et al. (2013) Disulfide stress-induced aluminium toxicity: molecular insights through genome-wide screening of Saccharomyces cerevisiae. Metallomics 5(8):1068-75 PMID:23832094
- Qian W, et al. (2012) The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep 2(5):1399-410 PMID:23103169
- Rodríguez-Porrata B, et al. (2012) Sip18 hydrophilin prevents yeast cell death during desiccation stress. J Appl Microbiol 112(3):512-25 PMID:22181064
- Venters BJ, et al. (2011) A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell 41(4):480-92 PMID:21329885
- Breslow DK, et al. (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5(8):711-8 PMID:18622397
- Mendiratta G, et al. (2006) The DNA-binding domain of the yeast Spt10p activator includes a zinc finger that is homologous to foamy virus integrase. J Biol Chem 281(11):7040-8 PMID:16415340
- Sopko R, et al. (2006) Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 21(3):319-30 PMID:16455487
- Giorgini F, et al. (2005) A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet 37(5):526-31 PMID:15806102
- Hellauer K, et al. (2005) Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae. Mol Pharmacol 68(5):1365-75 PMID:16061773
- Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91 PMID:12140549