Phenotype Help

ICS2 / YBR157C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.



Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

22 entries for 14 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chromosome/plasmid maintenance: decreased
heterozygous diploid, systematic mutation setnull
Allele: ics2-Δ
S288CAssay: diploid bimater (BiM) assay
Details: haploinsufficiency results in chromosome instability (CIN); scored >= 2 standard deviations above the mean
Choy JS, et al. (2013) PMID:23825022
chronological lifespan: increased
competitive growth

competitive survival of stationary phase co-cultures

null
Allele: ics2-Δ
S288CGaray E, et al. (2014) PMID:24586198
colony sectoring: increased
heterozygous diploid, systematic mutation setnull
Allele: ics2-Δ
S288CAssay: quantitative chromosome transmission fidelity (qCTF) assay
Details: >1.5 fold increase in mini-chromosome loss relative to wt, indicative of chromosome instability (CIN)
Zhu J, et al. (2015) PMID:25823586
competitive fitness: decreased
competitive growth overexpressionS288CDetails: decreased abundance within the barFLEX overexpression collection arrayed after 20 generations of pooled growth
Douglas AC, et al. (2012) PMID:23050238
competitive fitness: increased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: ics2-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 1.001
Breslow DK, et al. (2008) PMID:18622397
competitive fitness: increased
systematic mutation setnull
Allele: ics2-Δ
S288CMedia: synthetic oak exudate medium, OAK
Qian W, et al. (2012) PMID:23103169
haploinsufficient
heterozygous diploid, competitive growth

genome-wide fitness profiling

null
Allele: ics2-Δ
S288CMedia: turbidostat growth in FPM medium
Details: Relative growth score: -0.0041
Pir P, et al. (2012) PMID:22244311
metal resistance: decreased
systematic mutation set overexpressionS288C25 μM cadmium dichlorideDetails: exacerbates toxicity
Chakrabortee S, et al. (2016) PMID:27693355
metal resistance: decreased
systematic mutation set overexpressionS288C2 mM copper(II) sulfateDetails: exacerbates toxicity
Chakrabortee S, et al. (2016) PMID:27693355
metal resistance: decreased
systematic mutation set overexpressionS288C20 mM manganese(II) chlorideDetails: exacerbates toxicity
Chakrabortee S, et al. (2016) PMID:27693355
Showing 1 to 10 of 22 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


Reset

Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.


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