Phenotype Help

ATG42 / YBR139W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.


Summary
Non-essential gene; in systematic studies null mutants accumulate alpha-amino acids and show sensitivity to cycloheximide, streptomycin and Congo Red

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

12 entries for 7 phenotypes


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

PhenotypeExperiment TypeMutant InformationStrain BackgroundChemicalDetailsReference
chemical compound accumulation: abnormal
systematic mutation setnull
Allele: atg42-Δ
S288C alpha-amino acidDetails: Significantly altered free amino acid profile (X^2- test p < 0.01)
Mülleder M, et al. (2016) PMID:27693354
competitive fitness: decreased
competitive growth

fitness profiling using complete deletion alleles

null
Allele: atg42-Δ
S288CMedia: minimal medium
Details: Relative fitness score: 0.998
Breslow DK, et al. (2008) PMID:18622397
resistance to chemicals: decreased
systematic mutation setnull
Allele: atg42-Δ
S288C45 ng/ml cycloheximideAlamgir M, et al. (2010) PMID:20691087
resistance to chemicals: decreased
systematic mutation setnull
Allele: atg42-Δ
S288C40 mg/ml streptomycinAlamgir M, et al. (2010) PMID:20691087
resistance to chemicals: decreased
systematic mutation setnull
Allele: atg42-Δ
S288C50 ug/ml Congo RedDetails: 1 on a scale of 1 to 3, where 3 indicates the highest sensitivity; growth < wt but > slt2 null
García R, et al. (2015) PMID:26341223
resistance to chemicals: increased
homozygous diploid, large-scale surveynull
Allele: atg42-Δ
S288C460 uM dieldrinGaytán BD, et al. (2013) PMID:23358190
resistance to chemicals: increased
large-scale survey

variomic library screening of ~10,000 alleles for each gene

unspecifiedS288C100 ng/ml cycloheximideHuang Z, et al. (2013) PMID:23416056
resistance to chemicals: increased
homozygous diploid, systematic mutation setnull
Allele: atg42-Δ
S288C0.1 mM chromium trioxideDetails: 200% greater growth than wt upon exposure to hexavalent chromium [Cr(vi)]
Johnson AJ, et al. (2016) PMID:27146641
resistance to chemicals: increased
systematic mutation set null
Allele: atg42-Δ
S288C6 μg/mL PolygodialKipanga PN, et al. (2021) PMID:34071169
vacuolar morphology: abnormal
systematic mutation set

screen all non-essential genes for inability to fragment vacuoles in response to salt addition

null
Allele: atg42-Δ
S288C0.4 M sodium chlorideDetails: small defect in vacuolar fragmentation
Michaillat L and Mayer A (2013) PMID:23383298
Showing 1 to 10 of 12 entries

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).


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