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IST2 / YBR086C Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.

Feature Type
ORF , Verified
Cortical ER protein involved in ER-plasma membrane (PM) tethering; one of 6 proteins (Ist2, Scs2, Scs22, Tcb1, Tcb2, Tcb3) that connect ER to PM, regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1 phosphatase to PI4P; required to locate Osh6, Osh7 in ER/PM contact site to allow phosphatidylserine transport from ER to PM; localizes to mother in small-budded cells, to bud in medium-, large-budded cells; mRNA transported to bud tip by actomyosin-driven process 1 2 3 4