Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.
A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.
53 entries for 27 phenotypesIncrease the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.
| Phenotype | Experiment Type | Mutant Information | Strain Background | Chemical | Details | Reference |
|---|---|---|---|---|---|---|
| anaerobic growth: decreased | systematic mutation set | null Allele: she1-Δ | S288C | Details: anaerobic growth on media supplemented with either ergosterol or cholesterol is reduced | Reiner S, et al. (2006) PMID:16251356 | |
| biofilm formation: decreased | systematic mutation set | null Allele: she1-Δ | S288C | Vandenbosch D, et al. (2013) PMID:24034557 | ||
| budding index: abnormal | classical genetics | overexpression | S288C | Sopko R, et al. (2006) PMID:16455487 | ||
| budding index: decreased | classical genetics | overexpression | Other | Details: G1 arrested cells considerably larger than control cells | Espinet C, et al. (1995) PMID:7762298 | |
| cell cycle progression in G2 phase: abnormal | classical genetics | overexpression | S288C | Details: see Table S8 for more details; shift towards 2C DNA content | Sopko R, et al. (2006) PMID:16455487 | |
| cell cycle progression: abnormal | systematic mutation set | overexpression | S288C | Details: accumulation of cells with a 2C DNA content and an increased percentage of large-budded cells indicative of a G2 or M phase delay or arrest | Niu W, et al. (2008) PMID:18617996 | |
| cell size: increased | classical genetics | overexpression | S288C | Details: see Table S7 for more details | Sopko R, et al. (2006) PMID:16455487 | |
| chromosome/plasmid maintenance: decreased | heterozygous diploid, systematic mutation set | overexpression | S288C | Details: mean frequency of loss of heterozygosity (LOH) at the CAN1 locus increased at least 2-fold; frequently accompanied by LOH at the MET6 locus indicating loss of the entire chr V | Tutaj H, et al. (2019) PMID:30244280 | |
| competitive fitness: decreased | systematic mutation set fitness profiling after 15 generations | null Allele: she1-Δ | S288C | Media: alkaline conditions, pH 8 | Giaever G, et al. (2002) PMID:12140549 | |
| competitive fitness: decreased | competitive growth fitness profiling using complete deletion alleles | null Allele: she1-Δ | S288C | Media: minimal medium Details: Relative fitness score: 0.907 | Breslow DK, et al. (2008) PMID:18622397 |
This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).
Click on a gene or phenotype observable name to go to its specific page within SGD; drag any of the gene or observable objects around within the visualization for easier viewing; click “Reset” to automatically redraw the diagram; filter the genes that share observable terms with the given gene by the number of terms they share by clicking anywhere on the slider bar or dragging the tab to the desired filter number.
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