Sequence Help

NCL1 / YBL024W Sequence

Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.


Aliases
TRM4
Protein Product
tRNA (cytosine-C5-)-methyltransferase
Feature Type
ORF , Verified
Description
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 1 2 3
EC Number
2.1.1.202

Resources