Gene Ontology Help

REC102-REC104 meiotic recombination initiation complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Required for the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by SPO11 (Q22236) during meiotic recombination. May act to bridge the MER2-MEI4-REC114 complex (CPX-1809) with SPO11 and SKI8 (Q02793). Required for SPO11 nuclear localization, chromatin association, and binding to hot spots. Preferentially localizes to sites on the structural axis, where the series of loops (10-20kb) that pairs of sister chromatids organise into are anchored.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA metabolic process, chromosome, nuclear chromosome, organelle, intracellular non-membrane-bounded organelle