Gene Ontology Help

26S Proteasome complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Multi-enzyme complex that functions as the primary degradation machinery for the selective turnover of surplus or damaged proteins within the cell. Proteins targeted for degradation are covalently labeled with polyubiquitin chains which are recognized and removed by the proteasome. The core contains the protease active sites (chymotrypsin-like, trypsin-like and peptidylglutamyl-peptide hydrolyzing) that perform the proteolysis reactions in an internal chamber. The regulatory particles act as a discriminating gateway for potential substrates. The base drives the mechanical substrate unfolding and translocation of the unstructured polypeptides into the degradation chamber of the core peptidase. The lid contains the deubiquitinating enzyme (DUB) RPN11 that cleaves polyubiquitin chains from targeted substrates as an essential step in proteasomal substrate processing.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, hydrolase activity, peptidase activity, catabolic process, proteolysis involved in protein catabolic process, proteasome complex