Gene Ontology Help

Doa10 E3 ubiquitin ligase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Transmembrane E3 ubiquitin ligase complex involved in the endoplasmic reticulum-associated degradation (ERAD) pathway, directing misfolded proteins to proteasomal degradation. Required for ERAD-C subpathway which degrades proteins with misfolded cytoplasmic domains. The Doa10 core complex acts together with the E2 ubiquitin conjugating enzymes Ubc6 (P33296) and Cue1-Ubc7 (CPX-2948) and also the Cdc48p-Npl4p-Ufd1p AAA ATPase complex (CPX-2946).
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, transferase activity, catabolic process, proteolysis involved in protein catabolic process, response to chemical, response to stress