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[Cu-Zn] Superoxide dismutase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Catalyzes the breakdown of two superoxide molecules into dioxygen and hydrogen peroxide in two asymmetrical steps using an essential copper atom in the active site of the enzyme. Reduction of the oxidized Cu(II) form of the enzyme by superoxide, releasing dioxygen (reaction 1), alternates with oxidation of the reduced Cu(I) form by another superoxide anion and two protons, generating hydrogen peroxide (reaction 2). Protects the cell guard against free radical species produced during cellular metabolism. SOD1 acquires its copper by forming a heterodimer with the copper chaperone, CCS (CPX-2267), which also is responsible for formation of an intramolecular disulfide bond required to increase the enzymatic activity from approximately 10 % in disulfide-reduced SOD1 to 100 % in disulfide-oxidized SOD1. The copper chaperone, CCS1 (CPX-2895), both delivers the copper and oxidises the disulfide bond. There is also evidence of CCS-independent activation of SOD1.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

oxidoreductase activity, biological process

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.