Gene Ontology Help

DNA-directed RNA polymerase III complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Catalyzes the transcription of RNA from an DNA template by acting as a nucleotidyl transferase that polymerizes ribonucleotides at the 3-prime end of an RNA transcript. Responsible for the transcription of genes encoding small structured RNAs such as tRNAs, the 7 SL lncRNA, spliceosomal U6 snRNA and ribosomal 5S RNA. Pol III machinery recognizes conserved promoter elements located within the transcribed region, generally the box A and box B sequences, which contribute to the D- and T-loops in the tRNA structure. RPC34, RPC31 and RPC82 play a role in transcription initiation whereas the RPC37-RPC53 heterodimer is crucial for the correct recognition of the termination signals of class III genes. RPC11 is required for RNA cleavage. Pol III is capable of reinitiating transcription more rapidly on the same gene after the first transcription cycle without being released (facilitated reinitiation), resulting in a higher initiation efficiency; this appears to require an RPC11-dependent conformational change of Pol III. The core complex is believed to assemble in the cytoplasm before being transported to the nucleus.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, RNA binding, nucleotidyltransferase activity, transferase activity, DNA-templated transcription, DNA-templated transcription initiation, DNA-templated transcription termination, biosynthetic process, cellular nitrogen compound metabolic process, transcription by RNA polymerase III, nucleus, organelle, RNA polymerase III complex