Gene Ontology Help

MMS2-UBC13 ubiquitin ligase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Ubiquitin ligase complex. Transfers the thioester-bound donor ubiquitin from Ubc13 onto the Mms2 catalytically inactive E2 variant. Functions in concert with RING E3 ubiquitin ligase RAD5 to catalyze the Lys-63-linked polyubiquitination of monoubiquitinated replication processivity factor PCNA (CPX-544). MMS2 positions the acceptor ubiquitin so that only Lys-63 approaches the active site cysteine of UBC13. This modification activates the recombination-like DNA damage-avoidance mechanism, in which the replicating polymerase avoids synthesis opposite damaged DNA by transient switching of the template, from the damaged DNA strand to the intact newly synthesized strand of the sister chromatid.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, transferase activity, RNA catabolic process, catabolic process, nucleobase-containing compound catabolic process, cytoplasm