Gene Ontology Help

Nucleotide excision repair factor 4 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

An ATP-dependent damage recognition factor required for repair of damaged, nontranscribed DNA, in a process whereby DNA is incised on both sides of the lesion, resulting in the removal of a fragment approximately 25-30 nucleotides long. Locates damage on the non-transcribed strand and in transcriptionally inactive regions of the genome, with ABF1 binding to specific sites increasing the efficiency of the repair process. RAD16 appears to generate superhelical torsion in the DNA in one direction originating from the ABF1-binding site and may remodel chromatin to generate the space for DNA repair synthesis. Subsequent to binding the DNA lesion, the NEF4 complex may serve as a nucleation site for the assembly of the other repair components for dual incision to occur.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, hydrolase activity, DNA damage response, DNA metabolic process, DNA repair, response to stress