Gene Ontology Help

CLB5-CDC28 kinase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Cyclin-dependent protein kinase complex required for the control of the cell cycle during S-phase where it is required to activate DNA replication. Essential for initiation of meiotic recombination because it phosphorylates Ser-30 of MER2, a meiosis-specific double-strand break (DSB) protein, which primes Mer2 for subsequent phosphorylation by DDK on Ser29, creating a negatively charged patch necessary for DSB formation. Also plays a role in enhancing DNA damage response and repair by targeting the chromatin remodeling factor Fun30.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

kinase activity, transferase activity, cellular response to DNA damage stimulus, response to stress, cyclin-dependent protein kinase holoenzyme complex