Gene Ontology Help

DBF2-MOB1 kinase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Role in exit from mitosis during the cell cycle. Once activated, translocates to the nucleus where it phosphorylates an unknown protein to dislodge CDC14 (Q00684) from NET1 (P47035), resulting in diffusion of CDC14 throughout the nucleus. Phosphorylates CDC14 on several sites that flank the C-terminal nuclear localization signal (NLS) sequences, thereby inhibiting the NLS. Because of this, phosphorylated CDC14 molecules that escape to the cytoplasm cannot efficiently return to the nucleus and dephosphorylate substrates such as CDH1 (P53197) and SWI5 (P08153). Phosphorylates chitin synthase CHS2 (P14180) to regulate cytokinesis.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

kinase activity, transferase activity, regulation of cell cycle, nucleolus, organelle, intracellular non-membrane-bounded organelle