Gene Ontology Help

TRAMP complex variant 5-1 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Recognises and bind to splicing-defective pre-mRNAs and spliced-out introns leading to their rapid degradation by the nuclear exosome (CPX-599). Adds a short oligo(A) tail to the RNA which is assumed to make it a better substrate for 3'-end degradation. There is evidence that the various TRAMP complexes (CPX-1678, CPX-1679, CPX-1680) exhibit some substrate specificity with TRAMP5-1 preferentially targeting the ITS1 spacer region of 35S pre-rRNA
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, helicase activity, nucleotidyltransferase activity, transferase activity, RNA catabolic process, catabolic process, cellular nitrogen compound metabolic process, nucleobase-containing compound catabolic process, TRAMP complex