Complex: TRAMP complex variant 4-2
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-1679
- Systematic Name
- AIR2:HUL4:MTR4:PAP2
- SGD ID
- SGD:S000218067
- Aliases
- TRAMP complex ; TRF4 complex ; Trf4/5–Air1/2–Mtr4 polyadenylation complex
- Description
- Recognises and bind to splicing-defective pre-mRNAs and spliced-out introns leading to their rapid degradation by the nuclear exosome (CPX-599). Adds a short oligo(A) tail to the RNA which is assumed to make it a better substrate for 3'-end degradation. There is evidence that the various TRAMP complexes (CPX-1678, CPX-1679, CPX-1680) exhibit some substrate specificity with TRAMP4-2 targetting RNAPII transcripts, particularly mRNA 5' ends, close to the transition start site and also the CUT, SUT, and XUT ncRNAs.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
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| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables 5'-3' RNA polymerase activity (BSR)
- enables RNA binding (BSR)
- enables RNA helicase activity (BSR)
- enables polynucleotide adenylyltransferase activity (BSR)
- Biological Process
-
- involved in RNA fragment catabolic process (BSR)
- involved in RNA polyadenylation (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- Delan-Forino C, et al. (2020) Substrate specificity of the TRAMP nuclear surveillance complexes. Nat Commun 11(1):3122 PMID: 32561742
- Falk S, et al. (2014) The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities. Mol Cell 55(6):856-867 PMID: 25175027
- Andersen KR, et al. (2008) Take the "A" tail--quality control of ribosomal and transfer RNA. Biochim Biophys Acta 1779(9):532-7 PMID: 18657638
Resources
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