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MutLbeta endonuclease complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Mn2+-dependent endonuclease which nicks a DNA strand containing a pre-existing nick, presumably to provide an entry site for a mispair excision reaction. Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. ATP binding induces a conformational change in the MSH2-MSH6 (CPX-1037) and MSH2-MSH3 (CPX-1036) complexes which converts these to a clamp form that slides along the DNA and leads to recruitment of MutLalpha (CPX-1666) , MutLbeta and MLH1-MLH3 (CPX-1668).. This complex has been proposed to be an accessory factor that acts in conjunction with MLH1-PMS1 (CPX-1666) in maintaining the genetic stability of simple sequence repeats, by suppressing recombination between slightly divergent or homeologous DNA sequences, and in the repair of heteroduplex sites present in meiotic recombination intermediates. It may play a role in regulating between different crossover pathways.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, DNA binding, hydrolase activity, ion binding, nuclease activity, DNA damage response, DNA metabolic process, DNA repair, response to stress, nucleus, organelle