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MutLalpha endonuclease complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Mn2+-dependent endonuclease which nicks a DNA strand containing a pre-existing nick, presumably to provide an entry site for a mispair excision reaction. Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. ATP binding induces a conformational change in the MSH2-MSH6 (CPX-1037) and MSH2-MSH3 (CPX-1036) complexes which converts these to a clamp form that slides along the DNA and leads to recruitment of MutLalpha, MutLbeta (CPX-1667) and MLH1-MLH3 (CPX-1668). Plays a major role in maintaining the genetic stability of simple sequence repeats, by suppressing recombination between slightly divergent or homeologous DNA sequences, and in the repair of heteroduplex sites present in meiotic recombination intermediates. The MLH1-PMS1 heterodimer acts as the major Mlh heterodimer in MMR and is thought to coordinate Msh-DNA binding with downstream repair factors.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, DNA binding, hydrolase activity, ion binding, nuclease activity, nucleus, organelle

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.