Gene Ontology Help

SPT4-SPT5 transcription elongation factor complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

An essential RNA polymerase II elongation factor which functions in the control of RNAP II processivity. Mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. Binds RNA in a sequence-specific manner by recognizing multiple AA repeat sequences and a region within the conserved NusG N-terminal (NGN) domain of SPT5 contacts the non-template strand of DNA both upstream of RNAPII and in the transcription bubble.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, RNA binding, biological process, nucleus, organelle, DSIF complex, transcription elongation factor complex