Gene Ontology Help

Nuclear cap-binding complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Binds co-transcriptionally to the 5-prime, m7GpppG-cap (m7G-cap) structures of all RNA polymerase II transcripts (mRNAs and pre-miRNAs). Required for processes such as pre-mRNA splicing through commitment complex and spliceosome formation, export of mRNA out of the nucleus in association with NPL3 (Q01560), degradation of nuclear mRNAs, primary miRNA processing and miRNA-mediated RNA interference. In the cytosol, importin-beta interacts with CBC-bound importin-alpha (CPX-1068) and promotes the dissociation of the RNA from CBC. Importin-complex-bound CBC gets reimported into the nucleus for reuse.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, mRNA binding, DNA-templated transcription, RNA catabolic process, RNA splicing, biosynthetic process, catabolic process, mRNA processing, nuclear transport, nucleobase-containing compound catabolic process, nucleobase-containing compound transport, nucleocytoplasmic transport, response to osmotic stress, response to stress, transcription by RNA polymerase II, transport, nucleus, organelle