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Chromatin assembly factor 1 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Catalyzes de novo assembly of nucleosomes onto newly synthesized DNA, involved in chromatin assembly following both DNA replication and some forms of DNA repair. Binds modified histones H3 and H4 and deposits them as a tetramer, preferentially onto replicating DNA, in a step coupled to the replication process. This is followed by deposition of a pair of dimers of histones H2A and H2B mediated by other factor(s) in a process not necessarily coupled to DNA replication. The histone core of nucleosomes consists of two copies of each of histones H2A, H2B, H3 and H4. CAF-1 nucleosome deposition is thought to be involved in heterochromatic silencing. CAF-1 is not required for yeast cell proliferation, suggesting other pathway(s) can compensate.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

chromatin binding, histone binding, DNA damage response, DNA metabolic process, DNA repair, DNA replication, cellular component assembly, chromatin organization, response to stress

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.