Gene Ontology Help

Mitochondrial isocitrate dehydrogenase complex (NAD+) Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
A tricarboxylic acid cycle enzyme which catalyzes the conversion of threo-Ds-isocitrate to alpha-ketoglutarate and carbon dioxide, important for regulatory control of mitochondrial energy metabolism. Allosterically regulated, activated by citrate and ADP, inhibited by ATP and NADH. Binds specifically and with high affinity to 5'-untranslated regions of yeast mitochondrial mRNAs.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

RNA binding, mRNA binding, oxidoreductase activity, biological process, mitochondrion, organelle