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DNA replication factor C complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
DNA-dependent ATPase that functions with PCNA (CPX-544) to confer processivity on DNA polymerase delta. RFC uses the energy of ATP binding and hydrolysis to recruit PCNA to DNA, break one clamp interface, and topologically link the clamp to primed template DNA during the duplication of chromosomal DNA prior to cell division. After loading PCNA, RFC then dissociates, allowing PCNA to function with Pol-delta RFC consists of five subunits in a spiral arrangement, each subunit being AAA+ family proteins, and the complex contains four ATP sites located at subunit interfaces. A cavity exists in the center of this protein spiral that accommodates double-stranded DNA. Conserved polar and positively charged residues line the cavity and interact with DNA. There is a gap between two subunits, RFC1 and RFC5, which may provide an exit path for single-stranded DNA from the central cavity.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, ion binding, DNA metabolic process, DNA replication

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.