Gene Ontology Help

PCNA homotrimer Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Role in DNA replication, repair, cell-cycle control, and chromatin remodeling. Exists as a double back-to-back homotrimeric ring which encircles double-stranded DNA and slides spontaneously across it. Loaded onto at template-primer junctions synthesized on unwound DNA during S phase in an ATP-dependent process by replication factor C (CPX-545), where it recruits replicative DNA polymerases and stimulates their activity. The process of chromatin assembly is tightly coupled to DNA replication or repair and the double homotrimer allows DNA polymerase delta to binds to one homotrimer whilst the chromatin assembly factor-1 CNOT7 binds to the other.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, enzyme regulator activity, regulation of DNA metabolic process, nucleus, organelle