Primary Literature
TEXT HERE
- Li N, et al. (2024) Parental histone transfer caught at the replication fork. Nature. PMID: 38448592
- Parkash V, et al. (2023) A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides. Nucleic Acids Res 51(20):11225-11238 PMID: 37819038
- Reusswig KU, et al. (2022) Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions. Nat Commun 13(1):7014 PMID: 36400763
- Pinto MN, et al. (2021) The [4Fe4S] Cluster of Yeast DNA Polymerase ε Is Redox Active and Can Undergo DNA-Mediated Signaling. J Am Chem Soc 143(39):16147-16153 PMID: 34559527
- Zhou ZX, et al. (2021) How asymmetric DNA replication achieves symmetrical fidelity. Nat Struct Mol Biol 28(12):1020-1028 PMID: 34887558
- Denkiewicz-Kruk M, et al. (2020) Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction. Int J Mol Sci 21(24) PMID: 33322195
- Meng X, et al. (2020) DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun 11(1):2437 PMID: 32415104
- Sui Y, et al. (2020) Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases. Proc Natl Acad Sci U S A 117(17):9440-9450 PMID: 32277034
- Bui DT and Li JJ (2019) DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis. Genetics 212(2):445-460 PMID: 31028114
- Jedrychowska M, et al. (2019) Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism. PLoS Genet 15(12):e1008494 PMID: 31815930
- Meng X, et al. (2019) Sumoylation of the DNA polymerase ε by the Smc5/6 complex contributes to DNA replication. PLoS Genet 15(11):e1008426 PMID: 31765372
- Park VS and Pursell ZF (2019) POLE proofreading defects: Contributions to mutagenesis and cancer. DNA Repair (Amst) 76:50-59 PMID: 30818169
- Barbari SR, et al. (2018) Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in <i>Saccharomyces cerevisiae</i>. G3 (Bethesda) 8(3):1019-1029 PMID: 29352080
- Bowen N and Kolodner RD (2017) Reconstitution of <i>Saccharomyces cerevisiae</i> DNA polymerase ε-dependent mismatch repair with purified proteins. Proc Natl Acad Sci U S A 114(14):3607-3612 PMID: 28265089
- Dmowski M, et al. (2017) Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint. PLoS Genet 13(1):e1006572 PMID: 28107343
- Garbacz M, et al. (2015) Fidelity consequences of the impaired interaction between DNA polymerase epsilon and the GINS complex. DNA Repair (Amst) 29:23-35 PMID: 25758782
- García-Rodríguez LJ, et al. (2015) A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1. Nucleic Acids Res 43(18):8830-8 PMID: 26250113
- Grabowska E, et al. (2014) Proper functioning of the GINS complex is important for the fidelity of DNA replication in yeast. Mol Microbiol 92(4):659-80 PMID: 24628792
- Sengupta S, et al. (2013) Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. Curr Biol 23(7):543-52 PMID: 23499531
- Zegerman P (2013) DNA replication: polymerase epsilon as a non-catalytic converter of the helicase. Curr Biol 23(7):R273-6 PMID: 23578873
- Kraszewska J, et al. (2012) Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ɛ, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae. Mutat Res 737(1-2):34-42 PMID: 22709919
- Deshpande AM, et al. (2011) Polymerase epsilon is required to maintain replicative senescence. Mol Cell Biol 31(8):1637-45 PMID: 21321081
- Muramatsu S, et al. (2010) CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast. Genes Dev 24(6):602-12 PMID: 20231317
- Nick McElhinny SA, et al. (2010) Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases. Proc Natl Acad Sci U S A 107(11):4949-54 PMID: 20194773
- Dhillon N, et al. (2009) DNA polymerase epsilon, acetylases and remodellers cooperate to form a specialized chromatin structure at a tRNA insulator. EMBO J 28(17):2583-600 PMID: 19629037
- Gambus A, et al. (2009) A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. EMBO J 28(19):2992-3004 PMID: 19661920
- Jaszczur M, et al. (2009) Defective interaction between Pol2p and Dpb2p, subunits of DNA polymerase epsilon, contributes to a mutator phenotype in Saccharomyces cerevisiae. Mutat Res 669(1-2):27-35 PMID: 19463834
- Sabouri N and Johansson E (2009) Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. J Biol Chem 284(46):31555-63 PMID: 19776424
- Jaszczur M, et al. (2008) Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae. Genetics 178(2):633-47 PMID: 18245343
- Lou H, et al. (2008) Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint. Mol Cell 32(1):106-17 PMID: 18851837
- Nick McElhinny SA, et al. (2008) Division of labor at the eukaryotic replication fork. Mol Cell 30(2):137-44 PMID: 18439893
- Sabouri N, et al. (2008) Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage. Nucleic Acids Res 36(17):5660-7 PMID: 18772226
- Bloom J and Cross FR (2007) Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication. Mol Cell Biol 27(3):842-53 PMID: 17116692
- Chilkova O, et al. (2007) The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA. Nucleic Acids Res 35(19):6588-97 PMID: 17905813
- Pursell ZF, et al. (2007) Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon. Nucleic Acids Res 35(9):3076-86 PMID: 17452367
- Pursell ZF, et al. (2007) Yeast DNA polymerase epsilon participates in leading-strand DNA replication. Science 317(5834):127-30 PMID: 17615360
- Asturias FJ, et al. (2006) Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy. Nat Struct Mol Biol 13(1):35-43 PMID: 16369485
- Azvolinsky A, et al. (2006) The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes. Genes Dev 20(22):3104-16 PMID: 17114583
- Seki T, et al. (2006) GINS is a DNA polymerase epsilon accessory factor during chromosomal DNA replication in budding yeast. J Biol Chem 281(30):21422-21432 PMID: 16714283
- Tsubota T, et al. (2006) Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae. J Biol Chem 281(43):32898-908 PMID: 16916794
- Bjergbaek L, et al. (2005) Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance. EMBO J 24(2):405-17 PMID: 15616582
- Franco AA, et al. (2005) Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C. Genes Dev 19(11):1365-75 PMID: 15901673
- Garg P, et al. (2004) Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication. Genes Dev 18(22):2764-73 PMID: 15520275
- Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 PMID: 14673157
- Kesti T, et al. (2004) Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase. J Biol Chem 279(14):14245-55 PMID: 14747467
- McConnell AD, et al. (2004) Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo. Mol Cell Biol 24(7):2605-13 PMID: 15024052
- Pavlov YI, et al. (2004) Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations. BMC Biol 2:11 PMID: 15163346
- Chilkova O, et al. (2003) The quaternary structure of DNA polymerase epsilon from Saccharomyces cerevisiae. J Biol Chem 278(16):14082-6 PMID: 12571237
- Edwards S, et al. (2003) Saccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesion. Mol Cell Biol 23(8):2733-48 PMID: 12665575
- Pospiech H and Syväoja JE (2003) DNA polymerase epsilon - more than a polymerase. ScientificWorldJournal 3:87-104 PMID: 12806123
- Shcherbakova PV, et al. (2003) Unique error signature of the four-subunit yeast DNA polymerase epsilon. J Biol Chem 278(44):43770-80 PMID: 12882968
- Snaith HA, et al. (2003) Ibp1p, a novel Cdc25-related phosphatase, suppresses Schizosaccharomyces pombe hsk1 ( cdc7). Curr Genet 44(1):38-48 PMID: 14508607
- Tsubota T, et al. (2003) Double-stranded DNA binding properties of Saccharomyces cerevisiae DNA polymerase epsilon and of the Dpb3p-Dpb4p subassembly. Genes Cells 8(11):873-88 PMID: 14622139
- Dua R, et al. (2002) In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase epsilon in insect cells. Purification and characterization. J Biol Chem 277(10):7889-96 PMID: 11756442
- Marchetti MA, et al. (2002) A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway. Proc Natl Acad Sci U S A 99(11):7472-7 PMID: 12032307
- Ohya T, et al. (2002) The DNA polymerase domain of pol(epsilon) is required for rapid, efficient, and highly accurate chromosomal DNA replication, telomere length maintenance, and normal cell senescence in Saccharomyces cerevisiae. J Biol Chem 277(31):28099-108 PMID: 12015307
- Mäkiniemi M, et al. (2001) BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. J Biol Chem 276(32):30399-406 PMID: 11395493
- Pavlov YI, et al. (2001) Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeast. Mutat Res 478(1-2):129-39 PMID: 11406177
- Dua R, et al. (2000) Subunit interactions within the Saccharomyces cerevisiae DNA polymerase epsilon (pol epsilon ) complex. Demonstration of a dimeric pol epsilon. J Biol Chem 275(37):28816-25 PMID: 10878005
- Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 PMID: 10801849
- Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 PMID: 10733584
- Ohya T, et al. (2000) Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae. Nucleic Acids Res 28(20):3846-52 PMID: 11024162
- Zou L and Stillman B (2000) Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol Cell Biol 20(9):3086-96 PMID: 10757793
- Kesti T, et al. (1999) DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability. Mol Cell 3(5):679-85 PMID: 10360184
- Tran HT, et al. (1999) The 3'-->5' exonucleases of DNA polymerases delta and epsilon and the 5'-->3' exonuclease Exo1 have major roles in postreplication mutation avoidance in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2000-7 PMID: 10022887
- Tran HT, et al. (1999) Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast. Genetics 152(1):47-59 PMID: 10224242
- Vandenbol M and Portetelle D (1999) Disruption of six ORFs on Saccharomyces cerevisiae chromosome X: the YJL069c gene of unknown function is essential to cell viability. Yeast 15(13):1411-7 PMID: 10509023
- Beckwith WH, et al. (1998) Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro. Biochemistry 37(11):3711-22 PMID: 9521689
- Burgers PM (1998) Eukaryotic DNA polymerases in DNA replication and DNA repair. Chromosoma 107(4):218-27 PMID: 9745046
- Jokela M, et al. (1998) The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. Nucleic Acids Res 26(3):730-4 PMID: 9443964
- Sugino A, et al. (1998) DNA polymerase epsilon encoded by cdc20+ is required for chromosomal DNA replication in the fission yeast Schizosaccharomyces pombe. Genes Cells 3(2):99-110 PMID: 9605404
- D'Urso G and Nurse P (1997) Schizosaccharomyces pombe cdc20+ encodes DNA polymerase epsilon and is required for chromosomal replication but not for the S phase checkpoint. Proc Natl Acad Sci U S A 94(23):12491-6 PMID: 9356477
- Halas A, et al. (1997) Involvement of the RE V3 gene in the methylated base-excision repair system. Co-operation of two DNA polymerases, delta and Rev3p, in the repair of MMS-induced lesions in the DNA of Saccharomyces cerevisiae. Curr Genet 31(4):292-301 PMID: 9108136
- Kamel D, et al. (1997) Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in mice. Biol Reprod 57(6):1367-74 PMID: 9408242
- Li Y, et al. (1997) Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. J Biol Chem 272(51):32337-44 PMID: 9405441
- Torres-Ramos CA, et al. (1997) Requirement of yeast DNA polymerase delta in post-replicational repair of UV-damaged DNA. J Biol Chem 272(41):25445-8 PMID: 9325255
- Tran HT, et al. (1997) Hypermutability of homonucleotide runs in mismatch repair and DNA polymerase proofreading yeast mutants. Mol Cell Biol 17(5):2859-65 PMID: 9111358
- Jackson SP (1996) The recognition of DNA damage. Curr Opin Genet Dev 6(1):19-25 PMID: 8791484
- Shcherbakova PV and Pavlov YI (1996) 3'-->5' exonucleases of DNA polymerases epsilon and delta correct base analog induced DNA replication errors on opposite DNA strands in Saccharomyces cerevisiae. Genetics 142(3):717-26 PMID: 8849882
- Shcherbakova PV, et al. (1996) Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerases. Mutat Res 369(1-2):33-44 PMID: 8700180
- Ayyagari R, et al. (1995) A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair. Mol Cell Biol 15(8):4420-9 PMID: 7623835
- Humphrey T and Enoch T (1995) Cell-cycle checkpoints. Keeping mitosis in check. Curr Biol 5(4):376-9 PMID: 7627552
- Navas TA, et al. (1995) DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Cell 80(1):29-39 PMID: 7813016
- Morrison A and Sugino A (1994) The 3'-->5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae. Mol Gen Genet 242(3):289-96 PMID: 8107676
- Budd ME and Campbell JL (1993) DNA polymerases delta and epsilon are required for chromosomal replication in Saccharomyces cerevisiae. Mol Cell Biol 13(1):496-505 PMID: 8417347
- Wang Z, et al. (1993) DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae. Mol Cell Biol 13(2):1051-8 PMID: 8423775
- Araki H, et al. (1992) DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae. EMBO J 11(2):733-40 PMID: 1537345
- Smiley JK, et al. (1992) The 66 kDa component of yeast SFI, stimulatory factor I, is hsp60. Nucleic Acids Res 20(18):4913-8 PMID: 1408806
- Burgers PM (1991) Saccharomyces cerevisiae replication factor C. II. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases delta and epsilon. J Biol Chem 266(33):22698-706 PMID: 1682322
- Yoder BL and Burgers PM (1991) Saccharomyces cerevisiae replication factor C. I. Purification and characterization of its ATPase activity. J Biol Chem 266(33):22689-97 PMID: 1682321