Gene Ontology Help

RPD3L histone deacetylase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Histone deacetylase recruited to promoters in association with specific transcription factors such as UME6 (P39001), ASH1 (P34233), IME1 (P21190), WHI5 (Q12416), and STB1 (P42845) where it acts as a promoter targeted regulator of transcription.. At the promoter region, RPD3 deacetylates specific lysine residues on histones H3 and H4 in a localized region spanning about two nucleosomes. May also act to promote nucleosome assembly like a histone chaperone and prevent RSC-dependent histone eviction from nucleosomes. During vegetative growth, the complex functions as a negative regulator for all genes, whereas upon nitrogen depletion it functions as a positive regulator early during meiosis.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, cellular component assembly, chromatin organization, protein-containing complex assembly, nucleus, organelle, Rpd3L complex, Sin3-type complex, histone deacetylase complex