Gene Ontology Help

Anthranilate synthase complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Catalyses the conversion of chorismic acid to anthranilic acid in the first step in the tryptophan branch of aromatic amino acid biosynthesis. Tryptophan-specific regulation of enzyme activity level occurs through feedback regulation by the end product of the pathway, regulated by a tryptophan regulatory element (62LLESAKTNNELDRYS76) within Trp2. Component I (Trp2) and Component II (Trp3) are required for glutamine-dependent ASase activity while component I can use ammonia as cosubstrate without need of complex formation. . The C-terminal half of Trp3 also has indole-3-glycerol phosphate synthase activity.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

lyase activity, amino acid metabolic process, biosynthetic process, cellular nitrogen compound metabolic process, small molecule metabolic process