Gene Ontology Help

ATG12-ATG5 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Acts as an E3-like ligase. This activity is dependent on ATP and two enzymes, ATG7 (P38862) an E1-like activating enzyme and ATG10 (Q07879) an E2-like conjugating enzyme. Required for lipidation of ATG8 (P38182) (e.g. to phosphatidylethanolamine) and associates with the vesicle membranes once bound to ATG16 (CPX-1849).
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

acyltransferase activity, transferase activity, catabolic process, cellular component assembly, organelle assembly, protein lipidation, vacuole organization, cytosol