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SEC61 protein-conducting channel complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Cotranslational protein conducting channel (PCC) that also assembles with the Sec62-Sec63 complex (CPX-3056) to form the post-translational translocon complex (CPX-3055). Transports secretory proteins across, and inserts integral membrane proteins into, the membrane of the endoplasmic reticulum. The ribosome with an emerging signal sequence is targeted to the membrane by the signal recognition particle (CPX-609) and its receptor. The Sec61 complex acts as a receptor for the ribosome via its cytosolic loops. The alignment of the ribosomal tunnel with a central pore of the PCC allows direct movement of the nascent chain from the ribosomal tunnel exit across or into the membrane. The SEC61 channel appears to be responsible for the transport of glycoproteins. Binds to the oligosaccharyl transferase complex variant 2 (CPX-1639) which selectively glycosylates nascent polypeptide chains in the endoplasmic reticulum.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

molecular function, transmembrane transport, transport