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R2TP co-chaperone complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Co-chaperone that plays a role in box C/D snoRNP assembly/maintenance, especially under stress conditions. Also involved in the proper accumulation of box H/ACA small nucleolar RNAs. Regulates the stability of phosphatidylinositol 3-kinase-related protein kinases (PIKKs) such as TEL1 (P38110) and MEC1 (P38111), which are required for checkpoint signaling. Newly synthesized PIKK interacts with TEL2, in the TEL2–TTI1–TTI2 complex (CPX-1422), assisted by HSP90 (P02829). Phosphorylated TEl2 then mediates the interaction between PIKK and R2TP complex to eventually lead to the proper assembly of PIKK.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

cellular component assembly, protein-RNA complex assembly, protein-containing complex assembly