Gene Ontology Help

Sir2-3-4 silent chromatin complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Required for transcriptional repression of the silent mating type loci, HML and HMR. Spreads from sites of nucleation by first deacetylating the H3 and H4 histone tails, and then binding stably to nucleosomes to silence promoters up to 3 kb from the telomeric repeat.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

chromatin binding, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, chromatin organization, chromatin silencing complex