AboutBlogDownloadExploreHelpYeastMineGet Data
Gene Ontology Help

HOPS tethering complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Multisubunit tethering complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis by cross-linking two membranes, and facilitating the formation of a SNARE complex during fusion. Required for the delivery of vacuolar proteins and homotypic fusion of vacuoles and controls the clearance of late endosomes and autophagosomes during heterophagy and autophagy through promoting fusion of these vesicles with the vacuole Controls homotypic vacuole-vacuole fusion by regulating vesicle docking to the vacuole through its interaction with soluble SNAREs (CPX-1887), the GTP-bound form of the Rab protein YPT7 (P32939) and phosphoinositides. HOPS indirectly facilitates trans-SNARE complex formation by tethering membranes then protects newly formed trans-SNARE complexes from disassembly by SEC17/SEC18 (P32602/P18759). Reduces the levels of noncanonical trans-SNARE complexes formed during fusion, and further reduces the capacity of these mismatched complexes to undergo fusion. HOPS function is regulated through phosphorylation of its VPS41 subunit by YCK3 which lowers its affinity for vacuolar lipids.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

organelle fusion, vacuole organization

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.