Gene Ontology Help

ESCRT-0 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
The ESCRT machinery consists of ESCRT-0 (this complex), -I (CPX-940), -II (CPX-1623), -III (CPX-1624) and -IV (VPS4 complex, CPX-334) and is required for the downregulation of cell-surface receptors and for the final membrane scission step during endocytosis. ESCRT-0 binds PI3P on endosomes and ubiquitinated cargo via VPS27, recruiting clathrin and sequestering ubiquitylated cargo in clathrin-coated microdomains. HSE1 recruits ESCRT-1 and initiates the multivesicular body (MVB) pathway.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ubiquitin-like protein binding, catabolic process, proteolysis involved in protein catabolic process