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COMA complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
Heterotetrameric subcomplex of a larger central kinetochore CTF19 complex (CPX-1156). COMA is part of a tridentate linker layer, which also contains the Ndc80 (CPX-548) and MIND (CPX-1186) complexes. Although the COMA, MIND, and Ndc80 complexes assemble independently, evidence suggests subsequent interactions. COMA is a platform onto which outer kinetochore proteins assemble, including microtubule-binding proteins. It is proposed to have a distinct function with respect to force generation and microtubule attachment. In the absence of COMA, there is bipolar binding without the generation of sufficient pulling force to cause centromere stretching and transient sister-chromatid separation. COMA requires CBF3 complex (CPX-1898) for assembly onto centromeric DNA. Different combinations of COMA subunits have been found, which may reflect the regulated steps in kinetochore assembly.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

biological process