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Gene Ontology Help

Kinetochore MIS12 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Required for normal chromosome alignment and segregation, kinetochore formation during mitosis, proper kinetochore microtubule attachments and for the spindle assembly checkpoint. The complex plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. Mis12/MIND is part of a tridentate linker layer, which also contains the Ndc80 (CPX-548) and COMA (CPX-1187) complexes. Evidence suggests interactions between COMA, MIND, and Ndc80 complexes. The Mis12/MIND complex is a platform onto which outer kinetochore proteins assemble, including microtubule-binding proteins. It is proposed to have a distinct function with respect to force generation and microtubule attachment. In the absence of MIND, there is bipolar binding without the generation of sufficient pulling force to cause centromere stretching and transient sister-chromatid separation. MIND requires CBF3 complex for assembly onto centromeric DNA. Different combinations of MIND subunits have been found, which may reflect the regulated steps in kinetochore assembly.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

biological process, nucleus, organelle, intracellular non-membrane-bounded organelle, kinetochore, spindle pole

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Cellular Component

Manually curated GO annotations reflect our best understanding of the basic cellular component for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.