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Nuclear MIS12/MIND complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.


Summary
A kinetochore complex that assembles independently onto centromeric DNA, required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules. MIND is part of a tridentate linker layer, which also contains the Ndc80 (CPX-548) and COMA (CPX-1187) complexes. Evidence suggests interactions between COMA, MIND, and Ndc80 complexes. MIND is a platform onto which outer kinetochore proteins assemble, including microtubule-binding proteins. It is proposed to have a distinct function with respect to force generation and microtubule attachment. In the absence of MIND, there is bipolar binding without the generation of sufficient pulling force to cause centromere stretching and transient sister-chromatid separation. MIND requires CBF3 complex for assembly onto centromeric DNA. Different combinations of MIND subunits have been found, which may reflect the regulated steps in kinetochore assembly.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

biological process, MIS12/MIND type complex, nuclear MIS12/MIND complex, spindle pole