Gene Ontology Help

DASH complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Heterodecameric component of the kinetochore necessary for accurate chromosome segregation, supporting the dynamic attachment of mitotic chromosomes to the ends of shortening spindle microtubules. DASH forms closed rings around microtubules with a large gap between the DASH ring and the microtubule cylinder. A DASH-microtubule interface is believed to form, in which extensions from DASH rings reach across a gap between the ring and the microtubule and dock on the microtubule wall. DASH rings spontaneously oligomerize in the presence of microtubules of the mitotic spindle. DASH rings are processivity factors that allow kinetochores to translate along a single microtubule without dissociating. Each DASH ring may contain from 16-30 heterodecamers. The NDC80 complex (CPX-548) can simultaneously bind and bridge across two DASH complex rings through a tripartite interaction, each component of which is regulated by IPL1 kinase (P38991). This ensures a consistent spacing between rings. The complex may also may serve as a link between the kinetochore and the mitotic spindle.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

cytoskeletal protein binding, regulation of cell cycle, organelle, DASH complex, mitotic spindle, spindle