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DNA mismatch repair MutSalpha complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Mismatch repair complex, involved in the recognition and repair of base-base and small insertion/deletion mismatches that appear as a consequence of DNA polymerase errors during DNA synthesis. The complex is most effective at repairing mismatches on the lagging strand of replication. Binding to a mismatched DNA which can bend, leads to stable association of MSH2 with DNA, inhibition of its ATP activity and formation of ATP-bound MSH2-MSH6 sliding clamps. When MSH6 is bound to mismatched DNA and MSH2 to ATP, the complex can recruit MutLalpha and initiate the repair process. Binding of MSH2-MSH6 to a mismatch and provides a recognition signal for interactions with repair proteins that are involved in subsequent steps.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ATP hydrolysis activity, DNA binding, hydrolase activity, ion binding, DNA damage response, DNA metabolic process, DNA repair, cellular nitrogen compound metabolic process, response to stress

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.