Gene Ontology Help

GTPase-Activating Protein BFA1-BUB2 complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Acts as a two-component GTPase-activating protein for TEM1 (P38987) GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. The BUB2/BFA1 GAP binds TEM1 GTPase at spindle poles, achieving an asymmetry during mitosis when the spindle is properly positioned, with the complex accumulating on the bud-directed old spindle pole. BUB2/BFA1 keeps TEM1 inactive until the spindle is properly oriented, thus inhibiting MEN activation. Upon spindle misalignment TEM1 localizes symmetrically on both SPBs and the Spindle Position Checkpoint (SPOC) inhibits TEM1 through the BUB2/BFA1 complex, thereby restraining the MEN until the spindle repositions correctly.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

enzyme regulator activity, regulation of cell cycle, signal transduction, Bfa1-Bub2 complex