Gene Ontology Help

Mitotic checkpoint complex, CDC20-MAD2 subcomplex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Acts at the spindle checkpoint, in a surveillance mechanism that mediates a metaphase delay, until all chromosomes are properly attached to the mitotic or meiotic spindle, by sequestering Cdc20, thus preventing the activation of the the ubiquitin ligase activity of the anaphase-promoting complex (CPX-760). This ensures all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

regulation of cell cycle, regulation of organelle organization, regulation of protein modification process, signal transduction