Complex: GET complex
Macromolecular complex annotations are imported from the Complex Portal. These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background.
- Curated by
- IntAct
- ComplexAc
- CPX-956
- Systematic Name
- GET1:GET2:GET3
- SGD ID
- SGD:S000217918
- Aliases
- GET insertase complex ; Golgi to ER Traffic complex
- Description
- Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. GET1 and GET2 act as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol, delivered to it by the GET4-GET5 transmembrane domain recognition complex (CPX-1861). Cooperates with the HDEL receptor ERD2 (P18414) to mediate the ATP-dependent retrieval of resident endoplasmic reticulum proteins that contain a C-terminal HDEL retention signal from the Golgi to the endoplasmic reticulum.
Complex Diagram
This diagram displays the protein subunits (blue) of the complex and how they interact with each other. Interactions with other relevant participants such as small molecules (purple), sub-complexes (yellow), and other subunits (red) are also shown. If a participant appears in the diagram with no lines connected to it, then its specific interactions with other participants are currently unknown.
Subunits
This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. A brief description is also provided for each participant in the table.
Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through its pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.
| Subunit | Description | Stoichiometry |
|---|
Gene Ontology
Gene Ontology (GO) terms that describe the function of a complex, the biological process in which it participates, or its cellular location. Click on a term for its definition and other objects annotated to that term.
- Molecular Function
-
- enables ATP binding (IDA)
- enables ATP hydrolysis activity (IDA)
- enables membrane insertase activity (BSR)
- Biological Process
-
- involved in protein insertion into ER membrane (IDA)
- Cellular Component
-
- located in endoplasmic reticulum membrane (BSR)
- located in integral component of endoplasmic reticulum membrane (BSR)
Shared Annotations
This diagram displays Gene Ontology terms (green) and subunits (blue) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). The shared GO terms or subunits can be visualized separately using the radio button at the bottom of the graph. Note: No diagram is shown ("No shared annotations") if there are less than 2 shared annotations (either GO terms or subunits of other complexes) between this complex and any other complexes.
References
List of references used specifically to curate the information on this page.
- McDowell MA, et al. (2020) Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex. Mol Cell 80(1):72-86.e7 PMID: 32910895
- Mariappan M, et al. (2011) The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature 477(7362):61-6 PMID: 21866104
- Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19 PMID: 16269340
Resources
IntAct | ModelArchive | PDB:3SJD | PDB:3ZS9 ... Show all Show fewer