Gene Ontology Help

CURI complex variant 2 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Plays a role in coupling ribosomal protein gene transcription and ribosomal RNA synthesis and processing. Acts to sequester the ribosomal protein (RP)-specific transcription factor, IFH1, to reduce transcription of RP genes during periods of growth inhibition. Upon growth inhibition, the key regulator of cell growth, TORC1 is inactivated, which leads to rapid release of IFH1 from the RP gene promoter. RNA polymerase I activity inhibits the ability of UTP22, a component of both this complex and the SSU processome, to titrate IFH1 from RPG promoters. The CURI complex also activate transcription of RP genes since the CK2 component of the CURI complex can phosphorylate IFH1 at the sites essential for strong binding to FHL1 at the RP promoters.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ion binding, kinase activity, transferase activity, DNA-templated transcription, biosynthetic process, cellular nitrogen compound metabolic process, protein phosphorylation, transcription by RNA polymerase I