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Gene Ontology Help

CURI complex variant 2 Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

Summary
Plays a role in coupling ribosomal protein gene transcription and ribosomal RNA synthesis and processing. Acts to sequester the ribosomal protein (RP)-specific transcription factor, IFH1, to reduce transcription of RP genes during periods of growth inhibition. Upon growth inhibition, the key regulator of cell growth, TORC1 is inactivated, which leads to rapid release of IFH1 from the RP gene promoter. RNA polymerase I activity inhibits the ability of UTP22, a component of both this complex and the SSU processome, to titrate IFH1 from RPG promoters. The CURI complex also activate transcription of RP genes since the CK2 component of the CURI complex can phosphorylate IFH1 at the sites essential for strong binding to FHL1 at the RP promoters.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

ion binding, kinase activity, transferase activity, DNA-templated transcription, biosynthetic process, cellular nitrogen compound metabolic process, protein phosphorylation, transcription by RNA polymerase I

Biological Process

Manually curated GO annotations reflect our best understanding of the basic biological process for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

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Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Molecular Function

Manually curated GO annotations reflect our best understanding of the basic molecular function for this protein complex. Manually curated annotations are assigned by curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all manually curated GO annotations for accuracy and completeness.

Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Qualifier Gene Ontology Term Annotation Extension Evidence Source Assigned On Reference

Shared Annotations

This diagram displays Gene Ontology terms (green) that are shared between the given macromolecular complex (black) and other yeast complexes (yellow). Note: No diagram is shown ("No shared annotations") if there are less than 2 shared GO annotations between this complex and any other complexes.