Gene Ontology Help

ISW1a chromatin remodeling complex Overview

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code.

ATP-dependent chromatin remodeling complex which modulates the structure of chromatin to regulate a variety of cellular processes, including DNA replication, repair, chromosome segregation and transcription. Slides mononucleosomes from the end to the center of DNA and requires the flexible, acidic patch of the histone H4 tail to efficiently dock its translocase on the nucleosome, for stimulating the ATPase activity and inducing nucleosome mobility. Positions histone octamers in dinucleosomes more specifically than in mononucleosomes. Regularly spaces nucleosomes in vitro every 175 bp. ISW1a bound to 33 bp of extranucleosomal DNA at both entry/exit sites is in an inactive conformation, activated on binding to extranucleosomal DNA at only one entry/exit site. ISW1a bound to only one extranucleosomal DNA makes a stable contact with nucleosomal DNA two helical turns from the dyad axis, and this interaction is lost when ISW1a is bound to extranucleosomal DNA at both entry/exit sites. Required for the transcriptional repression of a number of genes, this set differs from those repressed by ISW1b (CPX-636) with which it shares a catalytic subunit.
GO Slim Terms

The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and cellular components. The GO Slim terms listed here are the broader parent terms for the specific terms to which this gene product is annotated, and thus represent the more general processes, functions, and components in which it is involved.

DNA binding, ion binding, chromatin organization, Isw1 complex